CS Balkan Pharmaceuticals Ltd. (Moldova)
100 Tabs x 20mg Total 2000mg
Tamoxifen (Tamoxifen Citrate, Nolvadex)
General
This drug is a potent nonsteroidal anti-estrogen. It is indicated for use in estrogen dependent tumors, i.e. breast cancer. Steroid users take Nolvadex to prevent the effects of estrogen in the body. This estrogen is most often the result of aromatizing steroids.
Nolvadex can aid in preventing edema, gynecomastia, and female pattern fat distribution, all of which might occur when a man’s estrogen levels are too high. Also, these effects can occur when androgen levels are too low, making estrogen the predominant hormone. This can occur when endogenous androgens have been suppressed by the prolonged use of exogenous steroids.
Nolvadex works by competitively binding to target estrogen sites like those at the breast. This drug is not toxic nor have any side effects been seen in athletes who used the drug’ as an anti-estrogen. This drug is the most popular anti- estrogen amongst steroid users. Although it does not turn out to be 100% effective for everyone, it does seem to exhibit some level of effectiveness for the majority.
It works so well for some bodybuilders they can take drugs like Anadrol right up to a contest as long as they stack it with Nolvadex. It would seem wise to take this drug in conjunction with any steroid cycle. Most reported a dosage of 10 mg to 20 mg daily got the job done.
Women’s usage
Tamoxifen is an orally active selective estrogen receptor modulator (SERM) that is used in the treatment of breast cancer and is currently the world’s largest selling drug for that purpose.
Breast cancer treatment
Tamoxifen is currently used for the treatment of both early and advanced ER+ (estrogen receptor positive) breast cancer in pre- and post-menopausal women. It is also approved by the FDA for the prevention of breast cancer in women at high risk of developing the disease. It has been further approved for the reduction of contra lateral (in the opposite breast) cancer.
Other uses
Tamoxifen is used to treat infertility in women with anovulatory disorders. A dose of 10–40 mg per day is administered in days 3–7 of a woman’s cycle. In addition, a rare condition occasionally treated with tamoxifen is retroperitoneal fibrosis.
In men, tamoxifen is sometimes used to treat gynecomastia that arises for example as a side effect of antiandrogen prostate cancer treatment. Tamoxifen is also used by bodybuilders to prevent or reduce drug-induced gynecomastia caused by the estrogenic metabolites of anabolic steroids.
Tamoxifen has been shown to be effective in the treatment of mania in patients with bipolar disorder by blocking protein kinase C (PKC), an enzyme that regulates neuron activity in the brain. Researchers believe PKC is over-active during the mania in bipolar patients.
Side effects
Tamoxifen is a selective estrogen receptor modulator. Even though it is an antagonist in breast tissue it acts as partial agonist on the endometrium and has been linked to endometrial cancer in some women. Therefore endometrial changes, including cancer, are among tamoxifen’s side effects.
The American Cancer Society lists tamoxifen as a known carcinogen, stating that it increases the risk of some types of uterine cancer while lowering the risk of breast cancer recurrence. The ACS states that its use should not be avoided in cases where the risk of breast cancer recurrence without the drug is higher than the risk of developing uterine cancer with the drug.
For some women, tamoxifen can cause a rapid increase in triglyceride concentration in the blood. In addition there is an increased risk of thromboembolism especially during and immediately after major surgery or periods of immobility. Tamoxifen is also a cause of fatty liver, otherwise known as steatorrhoeic hepatosis or steatosis hepatis.
A beneficial side effect of tamoxifen is that it prevents bone loss by inhibiting osteoclasts by acting as an estrogen receptor agonist (i.e., mimicking the effects of estrogen) in this cell type, and therefore it prevents osteoporosis. When tamoxifen was launched as a drug, it was thought that tamoxifen would act as an estrogen receptor antagonist in all tissue, including bone, and therefore it was feared that it would contribute to osteoporosis. It was therefore very surprising that the opposite effect was observed clinically. Hence tamoxifen’s tissue selective action directly lead to the formulation of the concept of selective estrogen receptor modulators (SERMs).
Advantages
- Potent nonsteroidal anti-estrogen
- You can buy Tamoxifen Citrate, Nolvadex here
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