Dong-A Pharmaceutical Co. (Korea)
4 Tabs x 100mg Total 400mg
Zydena (Udenafil)
Active Ingredient: Udenafil
Udenafil– trade name «Zydena ®» is one of the four molecules investigated for the treatment of erectile dysfunction with proven clinical efficacy, high safety and acceptability to the patient. The unique qualities of Zydena distinguish it from commercially available inhibitors of other members of the group focfodiesterazy fifth type.
Zydena enjoy rapid and predictable onset of action, duration of up to 24 hours, high in the class of PDE-5 inhibitors, the safety profile, Zydena not have testicular toxicity. Certainly, all of these properties will be the best in its segment.
The composition and the form of Udenafil
Tablets, film-coated light-pink color with light-yellow shade, oval shaped, imprinted with the symbol “100” on one side and symbols in the form of risk sharing letters “Z” and “Y” – to another, on a break – a white or nearly white .
1 tablet contains 100 mg udenafil;
excipients:
- lactose
- maize starch
- colloidal silicon dioxide
- L-hydroxypropylcellulose
- hydroxypropyl-LF
- talc
- magnesium stearate.
1 or 4 tablets per pack.
Pharmacological action of Udenafil
Zydena – a drug for treatment of erectile dysfunction. Is a reversible selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5).
Udenafil no direct relaxing effect on isolated corpus cavernosum, but enhances sexual stimulation relaxing effect of nitric oxide by inhibiting PDE-5, responsible for the breakdown of cGMP in the cavernous body. The result is relaxation of smooth muscles of arteries and blood flow to the tissues of the penis that causes erections. The drug has no effect in the absence of sexual stimulation.
Zydena improves erection and the possibility of successful sexual intercourse. The action of the drug has an optimal duration – up to 24 h. The effect is manifested as early as 30 minutes after taking the drug in the presence of sexual arousal.
In the study udenafil, men revealed no clinically significant effect on the drug quantity and concentration of sperm motility and morphology of spermatozoa.
Udenafil Indications
Treatment of erection disorders, characterized by the inability to achieve or maintain penile erection sufficient for satisfactory sexual intercourse.
Udenafil Dosing and Administration
Pills taken by mouth, with or without food, for 30 minutes before the alleged sexual activity.
Recommended dose – 100 mg. If necessary, taking into account individual performance and portability, the dose may be increased to 200 mg. The maximum recommended frequency of application – 1 times / day.
Udenafil Side effects
- flushing
- dizziness, eye pain
- increased lacrimation
- nasal congestion
- headache
Also noted: palpitations, prolonged erections.
Cautions
Sexual activity is a potential risk for patients with cardiovascular disease, hypertension, so treatment of sexual dysfunctions, including use of Zydena, should not hold for men with heart disease, in which sexual activity is not recommended.
Patients with obstruction of blood outflow from the left ventricle (aortic stenosis) may be more sensitive to the action of vasodilators, including inhibitors of PDE. Despite the lack of clinical trials of cases of prolonged erection (longer than 4 hours) and priapism (painful erection lasting more than 6 h), such phenomena are peculiar to this class of drugs. In the event of an erection lasting more than 4 hours (regardless of pain), patients should immediately seek medical help. In the absence of timely treatment of priapism can lead to irreversible damage to the erectile tissue and erectile function.
In the absence of clinical data on the use udenafil in patients older than 71 y.o. this category not recommended for patients taking the drug. Not recommended for use Zydena in combination with other treatments for erectile dysfunction.
Advantages
- rapid and predictable onset of action
- provides necessary to erection hardness
- increases the axial load on the penis
- reduces the time of the refractory period (time after ejaculation until the next erection)
- optimal duration of up to 24 hours
- high safety profile in the class of PDE-5 inhibitors
- Drinking alcohol and fatty food does not affect the action of udenafil
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