Deca-Durabolin / Nandrolone Decanoate

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Deca Durabolin [Nandrolone Decanoate]

Deca-durabolin is Organon tradename for extremely popular and widely used bulking anabolic steroid, which contains substance callednandrolone decanoate. Another less known but still very efficient nandrolone  ester is phenylpropionate  (Durabolin), which has shorter molecule, less sides but also less pronounced bulking effect. There are dozens of different brand names like Retabolin or Nandrolona-D, but we’ll call it “Deca” for short.

To make it clear – Deca has no oral bioavailability.

With proper diet and usage it reduces body fat, provides great strength and size gains and does not cause problems with the liver. At the same time it increases hematocrit level and bone density, therefore having positive effect not only in sport but also in treating certain forms of cancer,  anemia and osteoporosis, which is very important for females during menopause.

Main advantage of deca-durabolin is good anabolic effect and increased protein synthesis in muscle cells, which leads to superb muscle growth. However, protein building effect will occur in the body only if sufficient amount of calories and proteins is supplied, otherwise good results cannot be obtained.

Since Nandrolone stores more water in the connective tissues, it can temporarily ease or even cure existing pain in joints. This process is called water retention, which is more considerable comparing to using of injectable testosterones and it also leads to bigger outlook. Therefore, athletes who complain about pain in the shoulders, elbows, knees, can safely train with the aid of Deca-Durabolin.

Dosage of 400 mg per week also helps to accelerate recovery due to moderate androgenic effect of deca.

Dosage and usage

Athletes use Deca-Durabolin for muscle buildup and during bulking part of preparation for a contest because Deca promotes protein synthesis although other side of coin is water retention in the body. The dosage for men lies between 200 – 600 mg per week, the most common option is 400 mg. Scientific studies have shown that the best results can be achieved with 4 mg per 1 kg (2 mg/pound) of body weight.

At a dosage below 200 mg per week, the anabolic effects is very weak. 200-600 mg – anabolic effects growth rapidly with dosage. If dosage exceeds 600 mg / week, anabolic effect is still no more than effect of 600 mg  but side effects start killing all positive ones, so this dosage is not advisable. 1000mg is not better than 600 mg.

Beginners should use 200 mg/week, max 400 mg/week.

Inject deca-duraboline (nandrolone decanoate) in equal dosages twice a week deep in muscles, preferably buttocks.

Stacking

Deca-Durabolin is an effective steroid, which not only gives the desired results, but also goes well with other steroids in order to achieve a more rapid effect.

For muscle-build purposes deca very well combines with Dianabol (methandienone) and Testosterone. The classic Deca / Dianabol combo is for fast and strong gaining of muscle mass. Most athletes usually take 15 – 40 mg Dianabol per day and 200 – 400 mg Deca per week. Even faster results can be achieved with 400 mg of Deca / week and 500 mg Sustanon 250 / week.

Enormous gain in strength and muscle size could be achieved with 400 mg Deca, 500 mg Sustanon 250 / week and 30 mg of Dianabol /  day.

Professional users can combine deca with anapolon (anadrol/oxydrol) instead of dianabol.

A good startup stack is deca (deca durabolin, nandrolone decanoate) 400 mg/week + dianabol (danabol, naposim, methandienone) 40-50 mg/day. Length of cycle is 8 weeks. Don’t forget about anti-estrogen from the week 3 and 1 week after the cycle – tamoxifen or clomid (1 tab ED). For this cycle we advice you also using LIV-52 for liver protection

Using anti-estrogen for this cycle is important. Also, it restores natural test production. Using liv-52 is not absolutely necessary but makes this cycle completely safe.

For the whole 8 week cycle athlete needs: Deca: 3200mg, Dianabol” ~ 2240-2800 mg, Tamoxifen/Clomid: 50 tabs, Liv-52: 1 bottle.

Although Deca-Durabolin is not an optimal steroid when preparing for competition due to excessive water storage many athletes still achieve good results during this phase of preparation if they have sufficient time to “dry” afterwards. Alternatively, athlete may switch from long-acting deca to faster-acting ester duraboline (nandrolon-phenilpropionate) and thus avoid extra water retention.

Classic preparatory stack for contest is following: Deca-Durabolin 400 mg/week, Winstrol 50 mg/day, Parabolan 228 mg/week (every ampule contains 76 mg of substance) , and  Anavar (Oxandrolone) 25-30 mg/day (10 mg tabs).

Injectable Nandrolone (Deca-Durabolin) has no negative effect on the liver even if used for years UNLESS OVERDOSED. It can even be used by persons with liver diseases.

Even deca/dianabol combo negative effect on the liver could be eliminated quickly after user discontinues dianabol part.

Relatively  safe stack is a combination of Deca Durabolin 400 mg/week with Andriol 280mg / day. Both of these products are liver-friendly. However, PCT is still necessary.

Detection times

If doping tests are expected it is better to refrain from taking Deca Durabolin because its traces remain in the body for quite a long time.

In certain cases Nandrolone Decanoate (deca-duraboline) is detectable for up to 18 months (1 and 1/2 year) although this is an extreme occasion.

Side effects and PCT (Post Cycle Therapy) with deca

It’s not advisable to use nandrolone for the athletes below 21 y.o. and especially in prepubescent period because it might be very harmful for their health.

Due to relatively low androgenic ratio, aromatization (i.e. conversion into estrogen) with Deca used standalone appears only at a dose of 400 mg per week, although this does not mean that one should neglect it completely. Aromatization appears for all steroids with androgenic component and may result in growing breast (so-called “bitch tits”), female-pattern fat deposits, etc., so it’s much better to avoid such side effects by using anti-estrogen (see below).

Androgen-related side effects are unlikely to appear at dosages up to 400 mg but still should be considered. They include high blood pressure, blood clotting, which leads to frequent bleeding from the nose and a long healing of scratches, as well as increased production of the sebaceous gland and occasional acne. Some athletes also report headaches and sexual overstimulation. When very high doses are used over a prolonged period they can inhibit spermatogenesis. I.e., testes produce less testosterone because Deca-Durabolin, like almost all steroids, inhibits the release of gonadotropins from the hypophysis. To prevent this using of clomiphen/tamoxifen AFTER the cycle is must-do requirement.

Another common side effect of Deca-Durabolin is excessive water retention, which is not that bad in certain occasions, for instance pain in joints, but most athletes still want to avoid it.

Aromatization and partially water retention could be eliminated by use of proviron and tamoxifen (zymoplex, nolvadex, cytotam) or clomiphen. Take 1 tab of clomiphen/tamoxifen during the cycle, 3 tabs for the first day after it  and 2 tabs / ED (every day) for two-three weeks afterwards. Proviron should be added in case of “heavy” cycle when action of tamo/clom is not sufficient.

Female usage

One of classic female stacks is Deca + Primobolan + winstrol depot or it’s variances Deca+oral primo / Deca+oral winstrol

Deca dosage up to 100 mg per week is normally quite safe for women. With higher dosages androgen-related side effects may occur. This is called virilization – irreversible appearing of deep “men’s” voice, increased growth of body hair, acne, increased libido, clitoris hypertrophy.

To avoid skin problems female athletes may use more fast-acting durabolin (nandrolon-phenilpropionate). 50-100 mg of Deca-Durabolin per week could be a good choice for them who are very sensitive to androgenic side effects.

But in most cases even long-acting Deca 50-100 mg/week is OK and female athletes may combine it with Anavar 10 mg/ ED (every day). Both compounds, when taken in a low dosage, have only slight androgenic component so that virilization side effects only rarely occur. Deca provides substantial muscle growth and Anavar provides measurable strength gain with very low water retention. Switching from deca to primobolan in this stack will make cycle even safer but gains will be lower, too.

Medical

  • International name: Nandrolone
  • Group: Anabolic steroid agent
  • Description of the active substance (INN): Nandrolone
  • Dosage form: solution for intramuscular injection (oil)

Characteristics:

Anabolic steroid drug. Comparing to testosterone has a higher, prolonged (3-4 weeks due to using of  decanoate ester) anabolic and low androgenic activity. Causes activation of gene regulators in the cell nucleus by binding to specific protein receptors on the cell surface of target organs and the formation of a complex receptor – nandrolone, which provides transport across the cell membrane of the last in hyaloplasm where it crosses the nuclear membrane into the cell nucleus.

Androgenic effect stimulates the synthesis of nucleic acids (DNA, RNA) and structural proteins (which is associated with increased absorption in the body of nitrogen, phosphorus, sulfur, and K +), amplification of tissue respiration and oxidative phosphorylation in skeletal muscle with accumulation macroergs (ATP, creatine phosphate).

Promotes fixation of Ca2 + in the bones, increase bone mass when treating osteoporosis, increases appetite, and muscle mass with a corresponding increase in body weight.

Accelerates the growth of male sex organs and development of secondary male sexual characteristics. Stimulates the secretory activity of androgen glands – male sex glands (activation process of spermatogenesis, sebaceous glands; in large doses causes suppression of Leydig cells and reduces the synthesis of endogenous sex hormones due to the oppression pituitary FSH and LH (negative feedback).

Anabolic effect of Deca-Durabolin is manifested activation of reparative processes in the epithelium (blanket and glandular), bone and muscle tissues by stimulating protein synthesis and structural components of cells. Increases absorption of amino acids from the small intestine (compared to a diet rich in protein), creating a positive nitrogen balance.

Stimulates the production of erythropoietin and activates anabolic processes in bone marrow, treats anemia along with Fe (iron) supplements.

Violates the synthesis of vitamin K-dependent plasma coagulation factors (II, V, VII, X) in the liver, changes the plasma lipid profile (cholesterol concentration increases and decreases – HDL) cholesterol, increases the reabsorption of Na + and water in the kidneys, contributing to the formation of edema.

It is effective in women with disseminated breast carcinoma.

Uses:

Diabetic retinopathy, progressive muscular dystrophy, infantile progressive atrophy syndrome (Verdniga-Hoffmann), states characterized by a negative balance of Ca2 + (senile and postmenopausal osteoporosis, prolonged treatment with corticosteroids).

Increased catabolic processes, depleting the resources of the body (chronic infections, extensive surgery, SCS-induced myopathy, dekubital sores, burns, severe trauma).
Anemia: against hyperazotemia with chronic renal failure, congenital aplastic anemia, aplastic anemia (with myelofibrosis, mieloskleroze, myeloid bone marrow aplasia, bone marrow metastases of malignant neoplasms, drug myelotoxicity and heavy metal salts).

As an aid in cytostatic therapy of cancer (except prostate cancer), inoperable (metastatic) breast carcinoma in women postmenopauznom period or after ovariectomy.

Pituitary dwarfism in children and adolescents (as adjuvant therapy in low therapeutic effect against the appointment of GH).

Contraindications:

Hypersensitivity, prostate cancer, breast cancer (in men), breast cancer (with metastases in the presence of hypercalcemia), severe hepatic failure, nephrosis, glomerulonephritis (nephrotic form), hypercalcemia (including history), pregnancy, prepubescent age.

Caution

Coronary artery disease, heart failure, marked atherosclerosis, myocardial infarction (including history), hypertension, stroke, chronic renal failure, epilepsy, migraine, diabetes, prostatic hypertrophy, liver failure, lactation (data on the penetration into breast milk no), children (up to 2 years – the efficacy and safety have not been established) and old age.

Side effects of deca-durabolin (nandrolone decanoate)

Men and women – the progression of atherosclerosis (increase of concentration of LDL and decrease HDL cholesterol concentrations), iron deficiency anemia, peripheral edema, dyspeptic symptoms (epigastric pain, abdominal pain, nausea, vomiting), abnormal liver function with jaundice, leukemoid syndrome (leukemia pain in long bones), hypocoagulation with a tendency to bleed, gepatonecrosis (dark stools, vomiting with blood, headache, discomfort, respiratory failure), hepatocellular carcinoma, hepatic purpura (dark urine, fecal discoloration, urticaria, or point makulear hemorrhagic rash on the skin and mucous membranes, sore throat or sore throat), cholestatic hepatitis (yellow coloration of sclera and skin, pain in the right upper quadrant, dark urine, discolored feces), increased secretion of the sebaceous glands, chills, increased or decreased libido, diarrhea, feeling overflow in the stomach, bloating, cramps, sleep disturbance.

For women: effects virilization (clitoral enlargement, deepening or hoarseness, and dis-amenorrhea, hirsutism, acne, steroid, oily skin) Hypercalcemia (CNS depression, nausea, vomiting, fatigue).

Men: in prepubertal – virilism (acne, penis, priapism, development of secondary sexual characteristics), idiopathic hyperpigmentation of the skin, slowing or stopping growth (calcification of the epiphyseal growth zones of long bones) in the period postpubertatnom – irritation of the bladder (increased frequency of desires), mammalgia, gynecomastia, priapism, decreased sexual function, the elderly – hypertrophy and / or carcinoma of the prostate.

Overdose

  • Symptoms: hepatotoxicity.
  • Treatment: gastric lavage, symptomatic therapy appointment.

Application and dosage:

Intramuscular, an average dose of 50 mg, 1 time every 3-4 weeks. If necessary, increase to 100 mg. Children: 0.4 mg / kg every 3-4 weeks. Duration of therapy to 12 months, if necessary, may repeat course of therapy after 4 weeks of break. In the treatment of severe conditions (including breast cancer, refractory anemia) may require higher doses, determined by comparing the therapeutic effects and the risks and benefits of therapy. Treatment against the background of high-protein diet.

When anemia (in conjunction with drugs Fe) – 100-200 mg (for women – 50-100 mg), 1 per week to stimulate anabolic processes – 50-200 mg (women – 50-100 mg), 1 in 1-4 weeks for children 2-13 years – 25-50 mg 1 every 3-4 weeks.

With carcinoma of the breast (nandrolone phenilpropionate) – 50-100 mg 1 time per week. Duration of treatment – individual.

When anemia in the background hyperazotemia with chronic renal failure and as an auxiliary drugs against cytostatic therapy is prescribed at a dose of 75 mg. Patients with severe chronic renal failure – 50 mg 1 time per week. V / m injection should be deep, preferably in the gluteal muscles.

Cautions:

In the course of treatment requires systematic monitoring of blood concentrations of Ca2 + (especially in patients with breast cancer and the presence of metastases in the bone), cholesterol (especially in patients with concomitant diseases CAS), glucose (diabetes mellitus), hematocrit, Hb, serum phosphorus, as well as the functional state of the liver.
The treatment must be ensured adequate intake of adequate amounts of protein, fat, carbohydrates, vitamins and minerals.

If you have menstrual irregularities and / or signs of virilization treatment should be discontinued.
Suppresses lactation.

The use of anabolic steroids to stimulate athletic qualities can cause serious health problems and is unacceptable.

The cold solution may become cloudy, in this case must be heated to dissolve the crystals vial before use.
Used with caution in children and adolescents due to the risk of premature closure of epiphyseal growth zones, early puberty in males and virilization in women. The acceleration of epiphyseal growth of long bones can be observed in children both during treatment and after 6 months after stopping treatment.
To monitor the status of the epiphyseal growth zones of long bones in children and adolescents is recommended radiographic study of every 6 months.

It should be noted that the use of anabolic steroids in elderly patients may contribute to the development of prostatic hyperplasia.

The feasibility of using anabolic steroids in osteoporosis is unclear (unproven efficacy and high risk of serious side effects.)

Interaction:

Enhances the effects of indirect anticoagulants, insulin and oral hypoglycemic drugs, antiplatelet agents.
Attenuates the effects of growth hormone and its derivatives (accelerates the mineralization of the epiphyseal growth zones of long bones).
GCS and ISS, corticotropin, Na +-containing drugs and foods rich in Na +, increase (each) fluid retention, increasing the risk of edema, increase the severity of acne.
Simultaneous with the appointment of hepatotoxic drugs increases the risk of liver problems.

Advantages

  • Highly anabolic effect, powerful but in muscle mass growth
  • Liver-friendly
  • The most popular injectable anabolic steroid worldwide
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