Human menopausal gonadotropin (hMG)
HMG is a mixture of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
It is used for stimulating hormones by triggering FSH, and also LH production in the body. This drug was originally designed for use in women where it stimulates the ovaries to produce multiple follicles, thus making their fertile abilities more viable.
HMG is a drug very similar to HCG and posesses some of its functions, but also it has additional benefit of FSH stimulation, while HCG (human chorionic gonadotropin) is known mainly for its LH stimulation. HM Gonadotropin injection was originally designed as a fertility drug. FSH (follicle stimulating hormone) effect can greatly induce higher sperm count production by the men’s body.
HM Gonadotropin hormone can be most effective when ran along with HCG and other LH stimulating drugs.
HMG vs HCG
How HMG aka Human Menopausal Gonadotropin differs from HCG and why it may be a better alternative to this mainstay of post cycle therapy.
Post Cycle Therapy or PCT for short is a must after you have finished a steroid cycle. If you want to keep the strength and muscle gains you worked so hard for when you were on the juice, you need to help return your own body’s hormonal levels back to normal – or all you hard work will be wasted. Many great PCT protocols have been outlined over the years, and many individuals have had success following them. Nevertheless, what works can always work better.
For years, bodybuilders used HCG to kick-start their HPTA after a cycle. There’s still a lot of debate as to how it should be used, but for simplicities sake it’s fair to say it should be administered once the testes show sign of atrophy. This makes sense since, contrary to popular belief, HCG (and HMG) do not “cure” or “recover” anything. They do not return testosterone levels permanently and they do not assure that production will return to normal. They simply give a temporary boost that can be extremely helpful when one’s hormonal system is suppressed and attempted to return to normal. It’s a little bit of a “head start” on recovery, but at some point, the body must produce hormones all on its own – otherwise, it really isn’t recovery, its just substituting one drug for another. This is why supplementation is also recommended at this time.
Now that we’re established exactly how these drugs work, let’s examine the differences.
The most significant disparity is in the fact that HCG mimics LH (luteinized hormone). It gives the body a false signal that LH is present and everything else responds accordingly. HMG actually elevates natural LH. Now to some, there’s little difference, but it’s always better when the body reacts in the most natural manner. There’s also less of a chance of building up a tolerance when this occurs. And in the case of HCG, tolerance is developed pretty quickly. That’s why excessive HCG use is not recommend. Use too much, too often, and it won’t work at all.
Exactly how much LESS suppressive HMG is appears to still remain speculative. But it’s a good guess that it’s less so.
There’s another, still empirical, opinion that HMG causes less of an estrogen spike. The use of HMG for bodybuilding purposes is so new there’s no way of proving this one-way or the other. Yet. But again, it stands to reason this is so.
One absolute difference between the two compounds is the fact that HMG raises FSH (Follicle Stimulating Hormone) and HCG does not. Again, this is due to the fact that HCG works synthetically and HMG stimulates the entire feedback loop. This is especially appealing since an increase in FSH means higher sperm count and ejaculate volume.
HMG dosage and usage
A typical dose of 75 Units a day for 2 weeks is sufficient for restoring normal testicular function and sperm count in males. If necessary, the dose of menotropins may be increased by 75 to 150 Units FSH and 75 to 150 Units LH every four or five days
Note: Dosage regimen may vary according to physician preference or patient response. f the ovaries are abnormally enlarged or the serum estradiol concentration is excessively elevated on the last day of menotropins therapy, human chorionic gonadotropin should not be given for that cycle.
Although HMG is relatively new to the steroid community there are already misconceptions surrounding its use. People fail to realize that recommended dosages in the enclosed literature are for the original purpose of drug – that of a fertility stimulant in women. For men’s purposes, a much lower dose is needed. A single shot of 75 i.u.’s may be all that’s necessary. You can even try spitting that up into two half shots over two days. Using more, will not do more. It will not elevate testosterone higher, or give you bigger balls so don’t even think about it.
To be used
immediately after the cycle, max two weeks long. Must be followed by clomiphene
Anecdotal feedback on HMG has been very positive. It seems to work at least as well as HCG and most users feel it’s superior. Until more is known it may be best to alternate between HCG and HMG. This may also have an additional benefit of lessening the desensitizing effects of HCG.
As mentioned, any LH stimulation is temporary so while you’re recovering it’s best to have every advantage. Supplements such as unleashed and POST CYCLE can make the most of natural hormone production and get you on the road to recovery faster.
HMG and HCG may be related but it looks like HMG is the bigger brother.
Length of treatment
You’ll start receiving hMG or pure FSH shots three days into your monthly menstrual cycle and continue taking them for seven to 12 days each month, depending on how long it takes your eggs to mature. Your doctor will train you or your partner to give the shots. She’ll also monitor you closely to see whether you’re responding to the medication — frequent trans-vaginal ultrasounds and blood tests are often necessary. When your eggs are mature, you’ll be given an hCG injection. You’ll most likely ovulate 24 to 36 hours later. You’ll either be sent home to have sex, or your doctor will schedule an intrauterine insemination for a day or two later.
Most women will go through a maximum of three to six drug cycles. Success rates don’t improve if you take the drugs longer, so if you try three or more times and don’t get pregnant, your doctor may increase the dosage or suggest another kind of treatment.
Side effects of HMG
You may notice abdominal tenderness, bloating, fluid retention, and weight gain, or have a hard time giving yourself an injection. The newer, purer gonadotropins such as Gonal F and Follistim cause fewer side effects and can be injected using smaller needles subcutaneously (under your skin). Repronex can also be injected subcutaneously.
You’ll also have a 10 to 40 percent chance of conceiving twins or more with these fertility drugs. Though many couples consider this a blessing, multiple fetuses increase your risk of miscarriage and other complications.
Original female usage
ovarian syndrome, luteal phase defects, or an unexplained fertility problem. If you’re undergoing an assisted reproductive technology (ART) treatment such as in vitro fertilization (IVF), gonadotropins can help you produce several eggs for the procedure.
Gonadotropins can also help men who have a hormonal imbalance (that originates in the pituitary gland or hypothalamus) linked to a low sperm count, or poor sperm quality or motility (its ability to move). (See more information about fertility drugs for men.)
Treatment: What to expect
HMG consist of FSH and LH, while urofollitropin or recombinant FSH are made purely of FSH. Whichever you choose to be injected with for seven to 12 days will translate into a dose of FSH that’ll prompt your ovaries to produce several eggs, whereas you normally produce only one a month.
After you receive those shots, you’ll be injected with another substance called HCG, which will tell your ovaries to release your mature eggs into your fallopian tubes. If an egg meets up with a healthy sperm on its way to your uterus, you’ll have a chance to conceive.
This treatment can be a very hands-on, emotionally intense process, too, since you’ll have to go the doctor’s office for frequent monitoring. Find a willing friend, support group, or professional to talk to before, during, and after your treatment. (See therapists’ top ten tips for coping with a fertility problem. Also, visit the BabyCenter Community to discuss Clomid and similar fertility drugs with others.)
Women who take fertility drugs sometimes develop ovarian hyperstimulation syndrome (OHSS), a condition signaled by weight gain and a full, bloated feeling. Some patients also have shortness of breath, dizziness, pelvic pain, nausea, and vomiting. OHSS occurs when you respond too well to the drugs and produce too many eggs; your ovaries rapidly swell to several times their size and leak fluid into your abdominal cavity. Normally this resolves itself with careful monitoring by your physician. But in rare cases it can be life threatening, and you have to be hospitalized for more intense monitoring.
On the bright side, researchers who recently examined the results of eight different studies conducted between 1989 and 1999 found that fertility drugs don’t increase a woman’s risk of developing ovarian cancer, even if she takes them for more than a year. Previously this issue was a major source of controversy and concern.
Between 20 and 60 percent of women who use this treatment conceive (the wide range is due to all the other factors affecting pregnancy, from the time you have sex and your age to the speed and agility of your partner’s sperm). Very little information is available on the live birth rate for fertility drugs, but a few studies put the number at 70 to 85 percent.
- Intramuscular injection
- Humegon, Pergonal & Repronex;
- Subcutaneous injection
Demonstrated ovulatory dysfunction with:
- No current pregnancy
- No evidence of primary ovarian failure
- No uncontrolled thyroid or adrenal dysfunction
- No ovarian cysts (except in case of PCOS)
- Used in conjunction with hCG
In women, inducing ovarian follicular growth and maturation. In men, used to treat hypogonadotropic hypogonadism, and to induce spermatogenesis (sperm production).
How does it work?
Possesses hormonal activities of FSH and LH.
- Suggested Evaluations
- thyroid disease
- ovarian enlargement or cyst formation
- uterine fibroid tumors
- undiagnosed unusual vaginal bleeding
- estrogen levels
- primary pituitary or ovarian failure or enlargement
- evidence of prostate cancer in men
- testicular failure
- renal and hepatic functions
- During RX
- mid-cycle urine LH test (OPK)
- estrogen levels
- progesterone levels
- mid-cycle ultrasound to detect follicle development
Dosage must be carefully determined for each patient, and may be changed during treatment cycle. During a fertility treatment cycle in women, from a ratio of 75 units FSH:75 LH to 150 units FSH:150 LH injected once daily for 5 days or more. For male treatment, 75 units FSH:75 LH units three times weekly for several months.
Keep refrigerated. Maintain BBT chart or other recommended cycle charting methods throughout treatment cycle. If self-injecting and miss a dose, take as soon as remember, but not as late as the following day. Do not double doses. Use prepared/mixed solution immediately and discard any unused medication.
Common side effects
- Injection site pain
- Lower abdomen tenderness
- Fluid retention
- Emotional irritability
- Breast discomfort
- Multiple births
- Side effects to report to your doctor
- Severe pain or swelling in lower abdomen or extremities
- Shortness of breath
- Vomiting or diarrhea
- Pregnancy Category X: May cause birth defects if used during pregnancy.
- Exercise caution if patient is breastfeeding.
- May result in ovarian hyperstimulation.
- May result in multiple births.
- Drug interactions or incompatibility
Packaging and storage
Store below 40 °C (104 °F), preferably between 15 and 30 °C (59 and 86 °F), unless otherwise specified by manufacturer.
- HMG increases the testosterone production in the testes very quickly and reliably, even more than HCG. Ideal for PCT.
- You can buy HMG (Human Menopausal Gonadotropin) here