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Cialis

Buy Cialis
20 mg tabs.

Cialis / Tadalafil

General

Tadalafil, sold under the name of Cialis is a new group of medication which allows adequate sexual stimulation, relaxes the blood vessels of the penis and helps erection. The recommended dose of Tadalafil is 20mg.

Cialis is the only drug which is not only fast acting (works in 30 minutes) but is also know to be effective for as long as 36 hours, thus enabling you to choose the moment that is just right for you as well as your partner. You can take Cialis in the morning and be ready for the right moment during that day, evening or even during the next day. Millions of men have benefited from Cialis as it works effectively in mild, moderate or severe erectile dysfunction.

The effect is only obtained with a satisfactory sexual stimulation.

Tadalafil relaxes muscles within the penis. This allows increased blood flow into the penis, necessary to achieve and maintain an erection.

Tadalafil is used to treat erectile dysfunction (impotence).

Tadalafil may also be used for purposes other than those listed in this medication guide.

Advantages

There are several reliable sources where you can buy anabolic steroids:

Averbol

buy averbol onlineAVERBOL 25®
Substance: Methandrostenolone / Metandienone
10ml vial contains 25 mg/ml, totally 250 mg
Manufacturer: British Dragon
Substance: Methandrostenolone / Metandienone

Averbol

AveAVERBOL 25® General information

10ml vial contains 25 mg/ml, totally 250 mg and has srong anabolic and androgenic effect. It has a great effect on protein metabolism and promotes protein synthesis. This effect manifests itself in by creating a positive nitrogen balance, supporting the builidup of protein and, thus, skeletal muscle mass. Methandienone also induces an improved sense of well-being.

Averbol 25 / Dianabol (D-BOL) / Methandrostenlone

Dianabol (17-alpha-methyl- -17beta-hydroxil-androsta- -l.4dien-3-on) is a new, orally applicable steroid with a great effect on the protein metabolism. The effect of Dianabol promotes the protein synthesis, thus it supports the buildup of protein. This effect manifests itself in a positive nitrogen balance and an improved well-being. The calcium balance is positively influenced as well: Dianabol promotes the calcium deposits in the bones. Dianabol is indicated in the treatment of all diseases and conditions in which an anabolic(protein-buildup promoting) effect and a generally roborizing (entire organism strengthening) effect can be obtained.

Dianabol is similar to the chemical structure of 17-alpha methytestosterone. Dianabol, therefore, has a very strong anabolic and androgenic effect which manifests itself in an enormous buildup of strength and muscle mass in its users. Dianabol is simply a “mass steroid” which works quickly and reliably. A weight gain of 2 – 4 pounds per week in the first six weeks is normal with Dianabol. The additional body weight consists of a true increase in tissue (hyper-trophy of muscle fibers) and, in particular, in a noticeable retention of fluids. Dianabol aromatizes easily so that it is not a very good drug when one works out for a competition. Excessive water retention and aromatizing can be avoided in most cases by simultaneously taking Nolvadex and Proviron (Masterlone) so that some athletes are able to use Dianabol until three to four days before a competition. The dosage spectrum, in particular for bodybuilders, weightlifters and powerlifters is very wide. It ranges from two tablets per day up to twenty or more tablets per day. Accordingly, an effective daily dose for athletes is around 15-40 mg/day.

The dosage of Dianabol taken by the athlete should always be coordinated with his individual goals. Steroid novices do not need more than 15-20 mg of Dianabol per day since this dose is sufficient to achieve exceptional results over a period of 8-10 weeks. When the effect begins to slow down in this group after about eight weeks and the athlete wants to continue his treatment, the dosage of Dianabol should not be increased but an injectable steroid such as Deca Durabolin in a dosage of 200 mg/week or Primobolan in a dosage of 200 mg/week should be used in addition to the Dianabol dose; or he may switch to one of the two above meintoned compounds. The use of testosterone is not recommended at this stage as the athlete should leave some free play for later. For those either impatient or more advanced, a stack of Dianabol 20-30 mg/day and Deca Durabolin 200-400 mg/day achieves miracles.

In fact, athletes who are not ambitious to compete will make highly satisfying progress with Dianabol. Competing athletes, more advanced athletes, and athletes weighing more than 220 pounds do not need more than 40 mg/day and in very rare cases 50 mg/day. It does not make sense to increase the number of Dianabol tablets immeasurably since fifteen tablets do not double the effect of seven or eight. Daily dosages of 60 mg+ usually are the result of the athletes ignorance or his plain despair, since in some athletes, due to the continued improper intake of steroids, nothing seems to be effective any longer. The simultaneous intake of Dianabol and Anadrol is not a good idea since these two compounds have similar effects.

The situation can be compared to the intake of ten or more tablets of one of these drugs per day. Those who are more interested in Strength and less in body mass can combine Dianabol with either Anavar or Winstrol tabs. The additional intake of an injectable steroid does, however, clearly show the best results. To build up mass and strength, Sustanon or Testoviron Depot at 250 mg+/week and/or Deca Durabolin 200 at mg+/week are suitable. To prepare for a competition, Dianabol has only limited use since it causes distinct water retention in many athletes and due to its high conversion rate into estrogen it complicates the athletes fat breakdown. Those of you without this problem or who are able to control it by taking Nolvadex or Proviron, in this phase should use Dianabol together with the proven Parabolan, Winstrol Depot, Masteron, Anavar, etc.

Since Dianabols half life time is only 3.2-4.5 hours 1 application at least twice a day is necessary to achieve a somewhat even concentration of the substance in the blood. Scientific tests continue to show that on days of intense workout compared to rest days, the half-life time of Dianabol is reduced even further so that an application three times daily appears sensible. Since Dianabol is also 17-alpha alkylated and thus largely protected against a loss in effect, it is recommended that the tablets be taken during meals so that possible gastrointestinal pains can be avoided. On the third day after discontinuing the intake of Dianabol, proof of the substance methandrostenolone (methandienone) in the blood is negative. This means that the tablets are no longer effective.

The athlete, however, should not proceed under the assumption that a urine test will be negative since the elimination of the metabolites of the substance methandrostenolone through the urine continues much longer. The maximum substance concentration of Dianabol reaches the blood after 1-3 hours. A simple application of only 10 mg results in a 5-fold inerease in the average testosterone concentration in the male (2). An important reason why Dianabol works well in all athletes is that the endogenous cortisone production is reduced by 50-70%. Thus, Dianabol considerably slows down the rate at which protein is broken down in the muscle cell.

Women should not use Dianabol because, due to its distinet androgenic component, considerable virilization symptoms can occur. Thereare, however, several female bodybuilders and, in particular female powerlifters who use Dianabol and obtain enormous progress with 10-20 mg/day. Women who do not show a sensitive reaction to the additional intake of androgens or who are not afraid of possible masculinization symptoms get on well with 2-4 tablets over a period not to exceed 4-6 weeks. Higher dosages and a longer time of intake bring better results; however the androgens begin to be noticeable in the female organism. No woman who continues to care about her femininity should take more than 10 mg/day and 50-100 mg of Deca Durabolin/week over 4-6 weeks.

Although Dianabol has many potential side effects, they are rare with a dosage of up to 20 mg/day. Since Dianabol is 17-alpha alkylated it causes a considerable strain on the liver. In high dosages and over a longer period of time, Dianabol is liver-toxic. Even a dosage of only 10 mg/day can increase the liver values; after discontinuance of the drug, however, the values return to normal. Since Dianabol quickly inereases the body weight due to high water retention, a high blood pressure and a faster heartbeat can occur, sometimes requiring the intake of an antihypertensive drug such as Catapresan.

Additive intake of Nolvadex and Proviron might be necessary as well, since Dianabol strongly converts into estrogens and in some athletes causes gynecomastia (“bitch tits”) or worsens an already existing condition. Because of the strongly androgenic component and the conversion into dihydrotestosterone. Dianabol has significant influence on the endogenous testosterone level. Studies have shown that the intake of 20 mg Dianabol/day over 10 days reduces the testosterone level by 30-40%. This can be explained by Dianabols distinct antigonadotropic effect, meaning that it inhibits the release of the gonadotropic FSH (follicle stimulating hormone) and LH (luteinizing hormone) by the hypophysis.

Another disadvantage is that, after discontinuance of the compound, a considerable loss of strength and mass often occurs since the water stored during the intake is again exereted by the body. In high dosages of 5O mg+/ day aggressive behavior in the user can occasionally be observed which, if it only refers to his workout, can be an advantage. In order to avoid uncontrolled actions, those who have a tendency to easily lose their temper should be aware of this characteristic when taking a high D-bol dosage. Despite all of these possible symptoms Dianabol instills in most athletes a “sense of well-being anabolic” which improves the mood and appetite and in many users, together with the obtained results, leads to an improved level of consciousness and a higher self confidence.

For years, the steroid black market has been the only supply source for athletes to get Dianabol where, proverbially, D-bol is available in all colors, forms, sizes, and under any imaginable name. Those, however, who are only interested in original compounds,should make sure that the selected compound is part of the list with common trade marks for methan-drostenolone (methandienone) or that the compound looks like the one in the photos following this description. According to our experience the Thailandian Anabol tablets and the Indian Pronabol-5 are the best compounds. The “Thai-landians,” as they are often called by their users, can be easily identified. They are pentagonally shaped, of pink color and indented. One thousand tablets are packaged in a plastic bag which is contained in a labelled plastic box the size of a drinking glass. Note that the manufacturing date and not the expiration date is printed on the label. The plastic box is usually also shrink-wrapped. The price for a 1000-package lies around $500-$ 1000 on the black market. The Indian Pronabol-5, simply called “Pronas,” is enclosed in an oblong box with ten strips of 10 tablets each. These tablets are round, white, and indented on one side. The original Pronas can be easily recognized since they come in a silver aluminum strip with a double bottom, and have a purple irnprint so that the tablets are invisible. Since the fake Pronabols are indented as well one must make certain not to purchase tablets in bulk or tablets contained in a normal push-through strip. Original Pronas, cost approximately $ 100 per package on the black market. Other easily available original compounds are the Polish Metanabol and the Czech Stenoion.

For a long time the Polish Metanabol was packaged in a small brown glass vial of 20 tablets each. Unfortunately, the tablets are not indented or marked so the contents of the vials can be easily substituted. Since 1994, Metanabol has only been available in blister strips of 10 tablets each, of orange color, and with their own packaging. The Czech Stenolon tablets have two indents on one side and Come in push-through strips of 20 tablets. Each push-through strip is included in a yellow-grey package. Note that there is no package insert since the entire user information is printed on the back of the small carton. On the black market usually only individual strips without packaging can be found since the packaging takes up too much room when smuggled. Because of the interesting price of these two compounds it is not unusual to find athletes who take tmentyor more tablets daily. The Rumanian Naposim contains 20 tablets in 2 blisters.

The Russian Dianabol is packaged in push-through strips of ten tablets each. Ten push-through strips are contained in a green box or are held together by a black rubber band and a rag similar to toilet paper. The imprint on the push-through strips is either blue or black. The tablets are not indented and it is of note that the substance amount is given in grams (0.005 g/tablet) Since the price is low the Russian Dianabol is often taken in two-digit quantities. Although the tablets cost only 2-4 cents in Russia, a price of $0.50 is quite acceptable on the black market. The situation with the Russian compound is a little different since, in the meantime, numerous athletes have experienced unusual side erfects with these tablets. They range from nausea, vomiting, and elevated liver values to real cases of illness which have forced one or more athletes to stay in bed for several days.

These tablets, however, have one thing in common: there is no doubt that they work powerfully. Due to the unusual number of side effects and simultaneously the positive effect, there is speculation that the Russian Dianabol is a simple 17-alpha methyltestosterone. Since Dianabol as already mentioned, a derivative of it, the two substances have similar effects. The fine difference, however is that oral 17-alpha methyltestosterone is clearly more androgenic and therefore causes more strain on the liver. Our opinion is that processing of the 17-alpha methyltestosterone in methandrostenolone was probably not carried out completely in the Russian Dianabol; consequently, several tablets contain a mix. It is also possible that during manufacturing of the Russian Dianabol old, expired, tablets were mixed with the produced substance and made into new tablets. We want to explicitly emphasize, however, that these are only speculations. Unfortunately, there are Already fakes of the Russian tablets available. They are only recognized as such after 1-2 weeks of their intake when “nothing happens.” dianabol, d-bol As said before, in our experience the best results can be obtained with the Thailandian Anabol tablets and the Indian Pronabol.

Advantages

  • Great effect on the protein metabolism
  • A weight gain of 2 – 4 pounds per week in the first six weeks
  • You can buy Averbol here

There are several reliable sources where you can buy anabolic steroids:

Arimidex

Buy Aromasin (Exemestane) / Arimidex (Anastrozole) exedrol (exemestane) Buy Anastrozole
Aromasin [Exemestane Tablets] British Dragon (Thailand)
Powerful anti-estrogen (reduces aromatization)		 Exedrol
CS Balkan Pharmaceuticals Ltd. (Moldova)
60 Tabs x 25mg Total 1500mg		 Anastrozole
CS Balkan Pharmaceuticals Ltd. (Moldova)

 

Aromasin [Exemestane Tablets] / Arimidex (Anastrozole) / Femara (Letrozole)

General

by Anthony Roberts — Aromasin (Exemestane) is one of those weird compounds that nobody really knows what to do with. What we generally hear about it makes it very uninteresting It’s a third generation Aromatase Inhibitor (AI) just like Arimidex (Anastrozole) and Femara (Letrozole). Both of those two drugs are very efficient at stopping the conversion of androgens into estrogen, and since we have them, why bother with Aromasin? It’s a little harder to get than the other two commonly used aromatase inhibitors, because it’s not in high demand, and there’s never been a readily apparent advantage to using it. And I mean lets face it: It’s awkward-sounding. Aromasin doesn’t have much of a ring to it, and exemestane is even worse. Arimidex has a bunch of cool abbreviations (“A-dex” or just ‘dex) and even Letrozole is just “Letro” to most people. Where’s the cool nickname for Aromasin/exemestane? A-Sin? E-Stane? It just doesn’t work. It’s the black sheep of AI‘s. And why do we even need it when we have Letrozole, which is by far the most efficient AI for stopping aromatization (the process by which your body converts testosterone into estrogen)?

Letro can reduce estrogen levels by 98% or greater; clinically a dose as low as 100 mcgs has been shown to provide maximum aromatase inhibition! So why would we need any other AI‘s? Well, first of all, estrogen is necessary for healthy joints as well as a healthy immune system. So getting rid of 98% of the estrogen in your body for an extended period of time may not be the best of ideas. This may be useful on an extreme cutting cycle, leading up to a bodybuilding contest, or if you are particularly prone to gyno, but certainly can’t be used safely for extended periods of time without compromising your joints and immune system.

So that leaves us with Arimidex, which isn’t as potent as Letrozole, but at .5mgs/day will still get rid of around half (50%) of the estrogen in your body. Problem solved, right? Use Arimidex on your typical cycles, and if you are very prone to gyno or are getting ready for a contest, use Letro.

But what about Post Cycle Therapy (PCT)?

I think at this point most people are sold on the use of Nolvadex (Tamoxifen Citrate) instead of Clomid for PCT, since both compete estrogen at the receptor site, both increase serum test levels, and both drugs may also alter blood lipid profiles favorably (6). But since 20mgs of Tamoxifen is equal to 150mgs of clomid for purposes of testosterone elevation, FSH and LH, but Tamoxifen doesn’t decrease the LH response to :LHRH:. I think most people agree to Nolvadex’s superiority for PCT.

I’ve always been in favor of using Nolvadex during PCT, along with an AI (Aromatase Inhibitor), because reducing estrogen levels has been positively correlated with an increase in testosterone so in my mind, it’s be beneficial to increase testosterone by as many mechanisms as possible while trying to recover your endogenous testosterone levels after a cycle. SO which AI do we use? Letro or A-dex? Well, why don’t we just keep using whichever one we used during the cycle, and add in some Nolvadex? Unfortunately, Nolvadex will significantly reduce the blood plasma levels of both Letrozole as well as Arimidex. So if we choose to use one of them with our Nolvadex on PCT, we’re throwing away a bit of money as the Nolvadex will be reducing their effectiveness.
This, of course, is where Aromasin comes in, at 20-25mgs/day.

Aromasin, at that dose, will raise your testosterone levels by about 60%, and also help out your free to bound testosterone ratio by lowering levels of Sex Hormone Binding Globulin (SHBG), by about 20% SHBG is that nasty enzyme that binds to testosterone and renders it useless for building muscle. But what about using it along with Nolvadex for PCT?

To understand why Aromasin may be useful in conjunction with Nolvadex while both Letro and A-dex suffer reduced effectiveness, we’ll need to first understand the differences between a Type-I and Type-II Aromatase Inhibitor. Type I inhibitors (like Aromasin) are actually steroidal compounds, while type II inhibitors (like Letro and A-dex) are non-steroidal drugs. Hence, androgenic side effects are very possible with Type-I AIs, and they should probably be avoided by women.
Of course, there are some similarities between the two types of AIs both type I & type II AI‘s mimic normal substrates (essentially androgens), allowing them to compete with the substrate for access to the binding site on the aromatase enzyme. After this binding, the next step is where things differ greatly for the two different types of AI’s. In the case of a type-I AI, the noncompetitive inhibitor will bind, and the enzyme initiates a sequence of hydroxylation; this hydroxylation produces an unbreakable covalent bond between the inhibitor and the enzyme protein. Now, enzyme activity is permanently blocked; even if all unattached inhibitor is removed. Aromatase enzyme activity can only be restored by new enzyme synthesis. Now, on the other hand, competitive inhibitors, called type II AI’s, reversibly bind to the active enzyme site, and one of two things can happen:

1.) either no enzyme activity is triggered or

2.) the enzyme is somehow triggered without effect.

The type II inhibitor can now actually disassociate from the binding site, eventually allowing renewed competition between the inhibitor and the substrate for binding to the site. This means that the effectiveness of competitive aromatase inhibitors depends on the relative concentrations and affinities of both the inhibitor and the substrate, while this is not so for noncompetitive inhibitors. Aromasin is a type-I inhibitor, meaning that once it has done its job, and deactivated the aromatase enzyme, we don’t need it anymore. Letrozole and Arimidex actually need to remain present to continue their effects. This is possibly why Nolvadex does not alter the pharmacokinetics of Aromasin.

Before we close the book on Aromasin, it’s worth noting that you can (and should) still use one of the non-steroidal AI‘s during your cycle to reduce estrogen, if necessary. When you are ready for PCT, you can then switch over to Aromasin and still experience the full effects of an AI, since there is no cross-over tolerance experienced between steroidal and non-steroidal AI‘s. Since Aromasin is about 65% efficient at suppressing estrogen, it’s certainly a very powerful agent, especially considering you won’t experience reduced effectiveness because of your concurrent use of Nolvadex or from any sort of tolerance developed by using other AI‘s on your cycle. There is also a decent amount of preclinical data suggesting that Aromasin has a beneficial effect on bone mineral metabolism that is not seen with non-steroidal agents, and it may also have beneficial effects on lipid metabolism that are not found in the non-steroidal Letro and A-dex.

Finally, as we’re going to be using Nolvadex for PCT anyway, and we ought to be using an AI with it for maximum recovery I think Aromasin- considering it’s compatibility with Nolvadex and beneficial effects on bone mineral content and lipid profile, has finally stopped being the black sheep of AIs and found a home in our Cycles.

Advantages

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Andropen 275

Andropen 275
Andropen 275 British Dragon (Thailand)
Mixture of 5 testosterones (British Dragon version of Sustanon)

Andropen 275

General

Andropen 275 is a universal steroid, which is considered as one of the most effective steroid drugs. It is represented by a mixture of 5 different testosterone esters. Each of them has unique mechanism of action and a life span. For example, a short-chained acetate ester is quickly released into the bloodstream and has a quick onset of a physiological reaction.

The other 4 esters have delayed release, more prolonged action and lower speed of absorption. Due to different speed of release and absorption Andropen provides a prolonged action, so there is no need for frequent injections.

The Effect of Andropen 275

As it is based on testosterone esters, its effects are peculiar to testosterone itself:

  • Increase of muscle mass and strength
  • Strengthening of joints and ligaments
  • Pain relief
  • Improvement of immunity
  • High motivation and good mood
  • Significant increase of endurance

As Testosterone is a major sexual hormone of males it can greatly increase libido. Its action is generally anabolic – increase of protein synthesis and thus muscle mass. In high doses it suppresses the synthesis of gonadotropin in hypophysis, meanwhile in low dosage stimulates it. Besides it is used as a cure for mammary gland cancer.

Usage

Andropen 275 is not recommended for individuals under the age of 18. Women should also avoid it, otherwise it will lead to virilization. Usually the course of Andropen 275 lasts for 42 days with a single injection of 300-600mg a week. Do not exceed the dosage. Consult your doctor before using the drug.

A  20ml vial contains:

  • 20mg of testosterone acetate/ml
  • 90mg of testosterone decanoate/ml
  • 45mg of testosterone propionate/ml
  • 45mg of testosterone phenylpropionate/ml
  • 75mg of testosterone cypionate/ml.

Side effects

In recommended dosages the side-effects are not likely to happen. However in case of overdose gynecomastia is possible. Generally the side-effects of Andropen coincide with side-effects of Testosterone. Post Cycle Therapy is needed after the cycle.

Package

Each 20 ml multidose vial contains 20 mg per ml of testosterone acetate, 90 mg per ml of testosterone decanoate, 45 mg per ml of testosterone propionate, 45 mg per ml of testosterone phenylpropionate, and 75 mg per ml of testosterone cypionate.

Advantages

  • a very powerful mixture of testosterone esters with prolonged action. There is no need for frequent injections.
  • You can buy Andropen 275 here

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Andriol

Andriol (Testosterone Undecanoate) [Restandol]Buy Andriol (Testosterone Undecanoate) [Restandol] [Testocaps] [Cernos Caps] – Sun Pharma (India)
The safest steroid available

Andriol (Testosterone Undecanoate) [Restandol]

General

Andriol is an oral steroid which is widely used in bodybuilding. It is also known as testosterone undecanoate. This substance has unique benefits and shortcomings. Some athletes take it in the gap between cycles, but those who concern with safety take it separately.
In the organism Andriol transforms into dihydrotestosterone with very low rate of estrogen conversion. Thus the side-effects connected with increased estrogen level are not likely. In order to bypass the liver pharmacologists have developed the capsule that contains specific fatty acids. Though not all amount of the drug transforms into testosterone as it is desired, this capsule allows Andriol to penetrate by means of lymphatic system, leaving the liver unaffected.

It is usually taken at the dose 240mg/day (6 capsules), nevertheless about 6.8% of the drug gets into blood, and the rest is quickly removed via kidneys. Thus this dosage provides quite moderate results. That is why it is not suitable for “powerful” steroid cycles, but rather for keeping the level of testosterone during post-cycle course.
Nevertheless it has its specific benefits. Due to low testosterone provision Andriol is considered to be one of the safest steroids and can be used even by women. Besides, in 1 week after the end of the cycle your doping test reaction will be negative, so one can use it as “pre-contest” steroid. And after all it doesn’t suppress endogenous testosterone untill you use it for too long or exceed the doses.

Dosage and usage

Testosterone undecanoate is usually taken at the dosage 6-12 capsules (240 -480mg every day). The dosage should be divided into 3 parts and taken at regular intervals. Don’t chew the capsules.

Combinations

When it is used between Tables of Cycles, Andriol is usually stacked with Anavar (Oxandrolone). This combination can keep the level of testosterone and reduce the loss of muscles. You can use this combination as a separate cycle, known for its safety: Andriol 240mg/day, Anavar 30mg/day, also Primobolan Depot (Methenolone Enanthate) may be added at the dosage (400-600mg/week) for 10-12 weeks. In this case Post Cycle Therapy is required only when Primobolan Depot is added. This combo is safe for old bodybuilders as well.
The other combo is Testosterone Undecanoate 240mg/week + Anavar 20mg/day + Deca-Durabolin 200mg/week for 10-12 weeks. Some anti-estrogens are needed after the cycle (Tamoxifen, Clomid). In some cases it can be combined with Testosterone Propionate to reduce the amount of injections.

Advantages

There are several reliable sources where you can buy anabolic steroids:

Anavar (Oxanol, Oxandrolone)

Anavar (Oxanol, Oxandrolone)
Anavar (Oxanol, Oxandrolone) CS Balkan Pharmaceuticals (Moldova)
Safe oral steroid used for strength and qualitymuscle mass

Anavar (Oxanol, Oxandrolone, Oxandrin)

General

Oxandrolone is a weak steroid with only a slight androgenic component. It has been shown that Oxandrolone, when taken in reasonable dosages, rarely has any side effects. This is appreciated since Oxandrolone was developed mostly for women and children. Oxandrolone is one of the few steroids which does not cause an early stunting of growth in cluildren since it does not prematurely close the epiphysial growth plates. For this reason Oxandrolone is mostly used in children to stimulate growth and in women to prevent osteoporosis. Oxandrolone causes very light virilization symptoms, if at all. This characteristic makes Oxandrolone a favored remedy for female athletes since, at a daily dose of 10-30 mg, masculinizing symptoms are observed only rarely.

Bodybuilders and powerlifters, in particutar, like Oxandrolone for three reasons. First, Oxandrolone causes a strong strength gain by stimulating the phosphocreatine synthesis in the muscle cell without depositing liquid (water) in the joints and the muscles. Powerlifters and weightlifters who do not want to end up in a higher weight class take advantage of this since it allows them to get stronger without gaining body weight at the same time. The combination of Oxandrolone and 20 – 30 mg Halotestin daily has proven to be very effective since the muscles also look harder. Similarly good results can be achieved by a simultaneous intake of Oxandrolone and 120-140 mcg :clen: per day. Although Oxandrolone itself does not cause a noticeable muscle growth it can clearly improve the muscle-developing effect of many steroids.

Deca-Durabolin, Dianabol, and the various testosterone compounds, in particular, combine well with Oxandrolone to achieve a “mass buildup” because the strength gain caused by the intake of these highly tissue-developing and liquid-retaining substances results in an additional muscle mass. A stack of 200 mg Deca-Durabolin/week, 500 mg Testoviron Depot (e.g. Testoviron Ethanate 250)/week, and 25 mg Oxandrolone/day leads to a good gain in strength and mass in most athletes. Deca Durabolin has a distinct anabolic effect and stimulates the synthesis of protein; Oxandrolone improves the strength by a higher phosphocreatine synthesis; and Testoviron Depot increases the aggressiveness for the workout and accelerates regeneration.

Reasons

Mild

First of all, Oxandrolone is quite mild on your liver. It´s probably the mildest oral steroid available today. Dosages of up to 80mgs/day are easily tolerated by most men, and most side effects often found with other steroids are not common with. For this reason, Anavar is frequently the steroid of choice for many top level female bodybuilders and other athletes.

Due to its being a mild steroid in every sense of the word, high amounts of Anavar dosage are needed. It binds reasonably well to the AR, but pretty high doses are still needed and I would never suggest doing less than 20mgs/day. In fact, 20-80mgs are needed to start halting AIDS related wasting and recovering weight for burn victims so that´s the range I´d recommend keeping your dosages in concerning this compound. Personally, I´d use 100mgs/day if I were ever going to try this stuff. Any less than this amount (20-100mgs) would be a waste. For women, however, I think 2.5-10mgs/day would suffice. Virilation is not a concern with this compound, as it is only very mildly androgenic. Water retention is also virtually nil with it.

Does not aromatize

The second reason why Oxandrolone is so popular is that this compound does not aromatize in any dosage. As already mentioned, a certain part of the testosterone present in the body is converted into estrogen. This aromatization process, depending on the predisposition, can vary distinctly from the athlete to another. Oxandrolone is one of the few steroids which cannot aromatize to estrogen. This characteristic has various advantages for the athlete. With Oxandrolone the muscle system does not get the typical watery appearance as with many steroids, thus making it very interesting during the preparation for a competition. In this phase it is especially important to keep the estrogen level as low as possible since estrogen programs the body to store water even if the diet is calorie-reduced. In combination with a diet, Oxandrolone helps to make the muscles hard and ripped.

Although Oxandrolone itself does not break down fat, it plays an indirect role in this process because the substance often suppresses the athlete’s appetite. Oxandrolone can also cause some bloating which in several athletes results in nausea and vomiting when the tablets are taken with meals. The package insert of the Italian Oxandrolone notes its effect on the activity of the gastrointestinal tract. Some athletes thus report continued diarrhea. Although these symptoms are not very pleasant they still help the athlete break down fat and become harder. Those who work out for a competition or are interested in gaining quality muscles should combine Oxandrolone with steroids such as Winstrol Depot (Stanozolol), Parabolan Depot, Masteron, Primobolan Depot (Methenolone Enanthate), and Testosterone Propionate. A stack of 50 mg Winstrol Depot (Stanozolol) every two days, 5O mg Testosterone Propionate every two days, and 25 mg Oxandrolone every day has proven effective.

Another advantage of Oxandrolone’s non-aromatization is that athletes who suffer from high blood pressure or develop gynecomastia of the thymus glands when taking stronger androgenic steroids will not have these side effects with a this compound. The Oxandrolone/Deca-Durabolin stack is a welcome alternative for this group of athletes or for athletes showing signs of poor health during mass buildup with testosterone, Dianabol, or Anadrol (Anadrol 50 / Anapolon 50). Athletes over forty should predomi nantly use Oxandrolone.

Does’t influence the body’s own testosterone production

The third reason which speaks well for an intake of Oxandrolone is that even in a very high dosage this compound does not influence the body’s own testosterone production. To make this clear: Oxandrolone does not suppress the body’s own hormone production. The reason is that it does not have a negative feedback mechanism on the hypothalamohypophysial testicular axis, meaning that during the intake of Oxandrolone, unlike during the intake of most anabolic steroids, the testes signal the hypothalamus not to reduce or to stop the release of GnRH (Gonadotropin) and :LHRH:. This special feature of Oxandrolone can be explained by the fact that the substance is not converted into.For this reason Oxandrolone combines very well with Andriol, since Andriol does not aromatize in a dosage of up to 240 mg daily and has only slight influence on the hormone production. The daily intake of 280 mg Andriol and 25 mg Oxandrolone results in a good gain in strength and, in steroid novices, also in muscle mass without excessive water retention and without significant influence on testosterone production. As for the dosage of Oxandrolone, 8-12 tablets in men and 5-6 tablets in women seems to bring the best results.

About dosage and use

The rule of thumb to take 0.125mg/pound of body weight daily has proven successful in clinical tests. The tablets are normally taken two to three times daily after meals thus assuring an optimal absorption of the substance. Those who get the already discussed gastrointestinal pain when taking Oxandrolone are better off taking the tablets one to two hours after a meal or switching tu another campound. Since Oxandrolone is only slightly toxic and usually shows few side effects it is used by several athletes over a prolonged period ot time.

However Oxandrolone should not be taken for several consecutive months, since, as with almost all oral steroids it is 17-alpha alkylated and thus liver toxic. Oxandrolone is an all purpose remedy which, depending on the athlete’s goal, is very versatile. Women who react sensitively to the intake of anabolic steroids achieve good results when combining Oxandrolone/Primobolan Tabs and/or Clenbuterol, without suffering from the usual virilization symptoms. Women, however should not take more than 6 tablets daily. Otherwise, androgenic-caused side effects such as acne, deep voice, clitorial hypertrophy or increased growth of body hair can occur.

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Anadrol 50

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Anadrol 50 / Anapolon 50 [Oxydrol] (Oxymetholone)

General

Anadrol 50 (Oxymetholone) is an oral steroid which is used for bulking cycles. It is widely known for high anabolic rating – 320. Oxymetholone causes water retention, but in some cases it can be helpful to quickly increase the size of muscles and to get bulky appearance in a short time. As muscle cells absorb a lot of water, many bodybuilders look smooth, and sometimes even swollen.
Unlike other steroids, Anadrol 50 provides rather quantitative than qualitative gain of muscles, besides it greatly increases strength. This drug “lubricates” joints, therefore it became very popular among bodybuilders and powerlifters who have joint problems. In medical practice it is used as a cure for different disorders of blood formation.

Mechanism of action

By increasing the quantity of erythrocytes it lets muscles to consume more oxygen. Consequently it augments endurance which gives a feeling of endless strength. Due to high androgenic properties it induces regenerative mechanisms in an organism and thus reduces the risk of injury from excessive trainings.
Even after intense workouts an athlete has a feeling that he can do more. Though it is not a “steroid before a contest”, in hard workouts it can be much more helpful than other anabolics. That is why many bodybuilders stop using it one week before the contest and then take aromatase inhibitors and diuretics to get hard appearance.

Dosages

The usual dose is 50 -200mg daily, which is equal to 1-4 tabs. Do not exceed this dosage. The optimal dose is 3 tabs daily. You should begin the usage with 1 tablet a day, and after several days you can increase the dose to 2 tabs. Take them in the morning and in the evening along with meal.
In order to reduce water retention and increase the volume of solid muscles, supplement your cycle with Proviron and Nolvadex. If your weight exceeds 99 kg, you can switch to 3 tabs in the 3rd week. Nevertheless you shouldn’t take it in this dosage for more than 2-3 weeks.
After that you should reduce the dosage by 1 tab every following week. As Oxymetholone rapidly saturates receptors, the duration of a cycle shouldn’t be longer than 42 days. When you discontinue using Oxymetholone it’s better to take another steroid. Otherwise the noticeable decrease of muscle mass may occur. Usually after Anadrol cycle bodybuilders go on with Testosterone enanthate or Sustanon 250 during several weeks.
Athletes often stack it with Deca Durabolin or Testosterone. The following combination is rather efficient in gaining strength and mass but it is not for steroid novices: Anadrol 50 100mg a day, Parabolon 228mg a week, and Sustanon 500mg a week. We have to remind that Oxymetholone is not for beginners. Before using it bodybuilder should get some experience in using “moderate” substances and achieve some results.
There is a rumour that some professional bodybuilders take around ten tablets of Anadrol 50 a day. Don’t believe it, as human organism is not likely to stand it. You should take Anadrol seriously and do not exceed the dose under any circumstances. “The more, the better” is not correct in this case.

Side effects

Anadrol 50 is one of the most dangerous steroids. It has liver toxicity due to alkylation in 17-alpha position. After several weeks of usage there can be pathologic changes of liver functions. Since Anadrol is prone to aromatization it can cause gynecomastia and other estrogen-related side-effects. Thus anti-estrogens (Nolvadex, Proviron etc.) and diuretics are required before the contest.
If the usage of this drug caused acne, you can solve it by taking Accutane. Headaches, insomnia, lack of appetite, nausea, vomiting, stomach aches, diarrhea may also occur during your cycle. You can also feel general indisposition. This is different from other steroids which provide a general well-being. If you take high doses of Testosterone along with Oxymetholone, it may cause increased aggressiveness.
Since old athletes are more sensitive to side effects of Anadrol 50, they have more chances to get liver damage and prostate cancer. As the cycle is usually accompanied with calorie-rich diet your cholesterol level may increase.
Anadrol greately decreases the natural synthesis of testosterone, so HCG and Clomid is obligatory after the cycle to restore the function of testes.

Females and Anadrol 50

Women should avoid taking Anadrol 50 as it may cause all the symptoms of virilization, including acne, hypertrophy of clitoris, growth of beard, menstrual irregularities, hair loss etc. However, despite the risks some competitive female bodybuilders do use Anadrol to get enormous results. Those female athletes who wish to take advantages of Anadrol with low risks of side-effects should take it at the dosage 25mg every two days, along with “light” anabolics, e.g. Primobolan Depot or Deca Durabolin.

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Altraz

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Altraz *Generic Arimidex*, Anastrozole

General information

Altraz is produced in the form of tablets. It is widely used in bodybuilding to prevent estrogen-related side-effects (gynecomastia, water retention etc), caused by intake of testosterone or its derivatives. In medical practice it is used for treatment of breast cancer in women and low levels of testosterone in men. Though Arimidex is a powerful anti-estrogen (aromatase inhibitor), by chemical structure it doesn’t belong to steroids.

Usually it is used instead of Clomid or Nolvadex at the dosage of 0.25-1mg Every Other Day. For treatment of low level of testosterone the dosage maybe even less. It’s better not use it if you have high sensitivity to anastrozole or to its components. In case of problems consult your doctor.

The side-effects of Arimidex may depend on steroid you use. Usually they include headache, weakness, hot flashes, cough, skin rash, increased blood pressure, sweating. Rarely depression, weight gain, breast pain, nausea or vomiting may occur.

As an anti-estrogen Altraz (Arimidex) is used during steroid cycles containing high amounts of steroids which are prone to aromatization. If an athlete is susceptible to gynecomastia, it should be used even with medium quantity of these steroids. This drug can be more effective in estrogen reduction than aminoglutethimide (Cytadren), besides it does not possess aminoglutethimide specific side-effects.

Arimidex can greatly reduce estrogen level, but blood tests are needed to adjust the dose after 7 days of usage. Its action differs from other aromatase inhibitors, for instance Clomid or Nolvadex. The latter compounds inhibit estrogen receptors in some tissues and activate them in others. Meanwhile Anastrozole works on the whole.

While using Anastrozole during steroid cycle there is no necessity to take Clomid, but there are cases when it can also benefit you (for detailed information see Clomid). When the dosage of testosterone is moderate 0.5 mg a day of Anastrozole is usually enough to make good result.

 

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Acomplia

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Monaslim Remonabant – Generic Acomplia

Active Ingredient:  Rimonabant

What is Acomplia (Rimonabant)?

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Summary:

– A single pill has been found to stop both food andcigarette cravings enough to help people quit smoking and loseweight, and could also help curb other unhealthy urges.

– Named “Acomplia” the drug in one study helped people who wereoverweight drop an average of 20 pounds and in another doubledthe chances that smokers would quit.

– Rimonabant (which will be brought to market as Acomplia) worksby blocking the CB1 receptor, one of two receptors found in anewly described physiological system called the Endocannabinoid System (EC System), believed to play a critical role in theregulation of food intake and energy expenditure.

– Researchers wondered whether a drug that halted this action might curb appetite, and in 2001, the first animal study wasconducted at the National Institute of Alcohol Abuse andAlcoholism in Bethesda, Md.

– When the normal mice were given rimonabant, which blockedtheir CB1 receptors, the mice reduced their food intake.In 2002, Sanofi-Synthelabo began human testing.

– Acomplia works by selectively targeting and blocking the CB1receptors, helping normalize the over-activation of the ECsystem and making hunger or cigarette cravings more manageable.

– This blocking of signals that control cravings appears toresult in weight loss, improvement of cardiovascular/ metabolicrisk factors in overweight/obese patients and appears to reducetobacco dependence without post cessation weight gain in peoplewho smoke.

– Meridia (Reductil in Europe) was originally a drug meant totreat depressions and can have severe side-effects as well, likehigh blood pressure, sleeping problems (Insomnia), constipationand dry-mouth syndrome.

– This causes a lot of strain on many of the body systems and phentermine should therefore not be used for longer periods andonly in obesity cases and not for treating common overweight.

How Acomplia works?

The active ingredient is Rimonabant and it works byblocking the CB1 receptor, one of two receptors found in ourbody`s physiological system called the Endocannabinoid System (EC System). It is believed the EC system plays a critical role in the regulation of food intake and energy expenditure.

It works by selectively targeting and blocking CB1receptors, thus helping stabilize the over-activation of the EC system and managing hunger cravings in a better way.

Thus, once you can control cravings you will see significant results in weight loss and improvement of cardiovascular/metabolic risk factors normally found in overweight/obesepatients

What is the recommended dosage of Acomplia?

It should be taken once a day, before breakfast. Thenormally recommended dosage is 20mg which should beswallowed with a full glass of water.

What are the side effects of Acomplia?

Acomplia has certain minor side effects. However, these side effects are temporary in nature and go away once your body adjusts to the medication. These include:

  • Infections (Upper respiratory tract infection, Gastroenteritis)
  • Mood alterations
  • Memory loss
  • Dizziness, headache, irritability
  • Nausea, diarrhea, vomiting
  • Hot flush
  • Skin disorders
  • Tendonitis, muscle cramps or spasms
  • Asthenia/fatigue influenza

Rare side effects of Acomplia

  • Panic symptoms, anger and emotional disorder
  • Lethargy
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Roaccutance / Isotretinoin

Pharmacodynamics

Isotretinoin’s exact mechanism of action is unknown. Recent researchsuggests that the drug may amplify production of the antimicrobial proteinneutrophil-gelatinase associated lipocalin in the skin, thereby reducingsebum production.  Generally, it is thought that similar to otherretinoids, the drug alters DNA transcription.  The drug decreases thesize and sebum output of the sebaceous glands. It also stabilizeskeratinization, makes the cells that are sloughed off into the sebaceousglands less sticky, and therefore inhibits the formation ofcomedones.[citation needed] Isotretinoin’s combined impact on several ofacne’s contributory factors distinguishes isotretinoin from alternativeremedies such as antibiotics and accounts for its greater efficacy insevere, nodulocystic cases.

New studies have linked retinoids and other similar chemotherapy agents totelomere shortening, causing many to believe that telomere shortening isaccutane’s mechanism of action.Telomere shortening leads to an increase inthe rate of cell death within the body, which could possibly explain whyaccutane causes side-effects such as pre-epiphyseal closure, depression, andothers.

The effect on sebum production is temporary. However, remission of thedisease can be “complete and prolonged.”

Pharmacokinetics

Isotretinoin, when administered orally, is best absorbed when taken after ahigh fat meal, as it has a high level of lipophilicity. In a crossoverstudy, it was found that the peak plasma concentration more than doubledwhen taken after a high fat meal versus a fasted condition. Isotretinoin isprimarily (99.9%) bound to plasma proteins, mostly albumin. At least threemetabolites have been detected in human plasma after oral administration ofisotretinoin. These are 4-oxo-isotretinoin, retinoic acid and 4-oxo-retinoicacid. Isotretinoin also oxidizes, irreversibly, to 4-oxo-isotretinoin. Themetabolites of isotretinoin are excreted through both urine and feces. Themean elimination half-life is 21 hours, with a standard deviation from thismean of 8.2 hours.

Clinical use

Except in the most severe cases, isotretinoin is used only after other acnetreatments fail to produce results. Treatment of acne usually begins withtopical medications (e.g. benzoyl peroxide, adapalene, etc), followed byoral antibiotics (or a combination) and finally isotretinoin therapy. Thisis because other treatments, while less effective than isotretinoin, arethought to be associated with fewer adverse effects and lower cost. Thehigher cost is due to the medical supervision required in taking a toxicdosage. The cost of the medicine is also a factor (example: taking 5, 10, oreven 20 mg daily is far less expensive than taking 80 mg daily).

Indications

Isotretinoin is indicated for the treatment of severe cystic acne vulgaris.Many dermatologists also support its use for treatment of lesser degrees ofacne that prove resistant to other treatments, or that produce physical orpsychological scarring.

It is also effective for hidradenitis suppurativa and some cases of severeacne rosacea.  It can also be used to help treat harlequin ichthyosis,and is used in xeroderma pigmentosum cases to relieve keratoses.Isotretinoin has been used to treat the extremely rare conditionFibrodysplasia Ossificans Progressiva. It is also used for treatment ofneuroblastoma, a form of brain cancer.

Prescribing restrictions

In the United Kingdom, this drug may only be prescribed by, or under thesupervision of, a consultant dermatologist. Because severe, cystic acne hasthe potential to cause permanent scarring over a short period, restrictionson isotretinoin’s more immediate availability have proved contentious. Similar restrictions are common in most Australian states ֠in New SouthWales and Victoria, for instance, the prescriber must be a Fellow of theAustralasian College of Dermatologists (FACD). In New Zealand, isotretinoincan be prescribed by any doctor but is subsidised only if prescribed by avocationally registered general practitioner or dermatologist.

Since 1 March 2006, the dispensing of isotretinoin in the United States hasbeen controlled by a FDA-mandated website called iPLEDGE ֠dermatologistsare required to register their patients before prescribing and pharmacistsare required to check the website before dispensing the drug. Theprescription may not be dispensed until both parties have complied. Aphysician may not prescribe more than a 30-day supply. A new prescriptionmay not be written for at least 30 days. Pharmacies are also under similarrestriction. There is also a 7 day window from the time the prescription iswritten in which the medication must be picked up at the pharmacy. If theoriginal prescription is lost, or pick-up window is missed, the patient mustre-qualify to have another prescription written. Doctors and pharmacistsmust also verify written prescriptions in an online system before patientsmay fill the prescription.

In at least Mexico and Colombia, this drug is of restricted use, and anofficial identification and patient signature is required by the pharmacies.

Dosage

10 mg capsule

The dose of isotretinoin a patient receives is dependent on their weight andthe severity of the condition. High dose treatments are administered between0.5 mg/kg/day to 2 mg/kg/day (usually at 0.5 to 1 mg/kg/day, divided intotwo doses), for a total treatment of 4ֶ months. A second course may be usedtwo months following the cessation of the initial course if severe acnerecurs. Efficacy appears to be related to the cumulative dose ofisotretinoin taken, with a total cumulative dose of 120ֱ50 mg/kg used as aguideline.  High dose treatments should only be used as a last resortdue to adverse side effects.

Nearly all patients achieve initial clearing of acne during high-doseisotretinoin therapy. Furthermore, about 40% observe complete and long-termremission of the disease following one course of isotretinoin, while another40% eventually develop less severe recurrent acne which is treatable withless invasive medications. The remaining 20% relapse significantly enough towarrant an additional course of isotretinoin.

Lower dosage treatments, such as 10-20mg/day (approximately half the highdosage treatments above), are also highly effective, with greatly diminishedside effects.  However, such lower dosage courses may be associatedwith higher relapse rates requiring additional courses of isotretinoin.

Preparations

Isotretinoin is marketed under many brand names by various manufacturers. Itis typically available as 5 mg, 10 mg, 20 mg, 30 mg and 40 mg capsules. Somebrands of oral isotretinoin include: Accure (Alphapharm), Accutane andRoaccutane (Roche), Aknenormin (Hermal), Amnesteem (Mylan), Ciscutan (Pelpharma),Claravis (Barr), Clarus (Prepharm), Isohexal (Hexal Australia), Istretinoin-A(Pharmathen), Isosupra (SMB Laboratories), Isotane (PacificPharmaceuticals), Isotroin (Cipla), Oratane (Douglas Pharmaceuticals),Atretin (Lafrancol), Nimegen (Medica Korea), Acnotin (Mega Lifesciences)and Sotret (Ranbaxy).

It is also available as a 0.05% topical preparation, marketed by Stiefelunder the trade name Isotrex or Isotrexin (with erythromycin).

Adverse effects

Increasingly higher dosages will result in higher toxicity, resemblingvitamin A toxicity.

Adverse drug reactions associated with isotretinoin therapy include:
Common: Mild acne flare, dryness of skin, lips and mucous membranes,infection of the cuticles, cheilitis, itch, rosacea, skin fragility, skinpeeling, rash, flushing, nose bleeds, dry eyes, diffuse alopecia areata, eyeirritation, conjunctivitis, reduced tolerance to contact lenses,hyperlipidaemia, raised liver enzymes, permanent thin skin, headaches,temporary/permanent hair thinning (this could start or continue aftertreatment), myalgia and/or arthralgia, back pain.

Infrequent: severe acne flare, raised blood glucose level, decreasedlibido/erectile dysfunction, increased erythrocyte sedimentation rate,fatigue.

Rare: impaired night vision; cataracts; optic neuritis; menstrualdisturbances; inflammatory bowel disease; pancreatitis; hepatitis; cornealopacities; papilloedema; idiopathic intracranial hypertension; skeletalhyperostosis; extraosseous calcification; psychosis; depression

There are spontaneous reports of premature epiphyseal closure in acnepatients receiving recommended doses of Accutane. The effect of multiplecourses of Accutane on epiphyseal closure is unknown.

The following adverse effects have been reported to persist, even afterdiscontinuing therapy: alopecia (hair loss), arthralgias, decreased nightvision, inflammatory bowel disease, degenerative disc disease, keloids, bonedisease. High dosages of isotretinoin have been reported to cause rosacea (adisease of severe facial skin redness and irritation).

Erectile dysfunction in the form of difficulty in maintaining erection wasreported in several patients in a clinical study.

While vitamin E supplements have been advocated by some to reduce thetoxicity of high-dose retinoids without reducing drug efficacy, test resultshave proven this to be false (though no indication of what form of vitamin Ewas used).

Patients with degenerative conditions, such as muscular dystrophy, shouldnot take isotretinoin as it may exacerbate and/or accelerate the underlyingcondition. This may be due to a suspected effect similar to acceleratedaging on the skin and tissues of the body, including muscle fibers.[citationneeded]

Patients receiving isotretinoin therapy are not permitted to donate bloodduring and for at least one month after discontinuation of isotretinointherapy due to its teratogenicity.

Teratogenicity (Birth Defects)

Isotretinoin is a teratogen and is highly likely to cause birth defects iftaken during pregnancy. A few of the more common birth defects that thisdrug can cause are hearing and visual impairment, missing or malformedearlobes, facial dysmorphism, and mental retardation. Isotretinoin isclassified as FDA Pregnancy Category X and ADEC Category X, and use iscontraindicated in pregnancy.

The manufacturer recommends that pregnancy be excluded in female patientstwo weeks prior to commencement of isotretinoin, and that they should usetwo simultaneous forms of effective contraception at least one month priorto commencement, during, and for at least one month following isotretinointherapy.

In the U.S. more than 2,000 women have become pregnant while taking the drugbetween 1982 and 2003, with most pregnancies ending in abortion ormiscarriage. About 160 babies with birth defects were born. Consequently,the iPLEDGE program was introduced by the U.S. Food and Drug Administrationon 12 August 2005 in an attempt to ensure that female patients receivingisotretinoin do not become pregnant ֠as of 1 March 2006, only prescribersregistered and activated in iPLEDGE are able to prescribe isotretinoin, andonly patients registered and qualified in iPLEDGE will be able to haveisotretinoin dispensed. The iPLEDGE program also applies to males, eventhough there has been no evidence of isotretinoin excretion through seminalfluids.

Depression

Several studies have suggested a possible link between isotretinoin andclinical depression.[38][39] Psychiatrist Dr. Doug Bremner found decreasedfrontal lobe function on brain imaging in patients treated with Accutane (isotretinoin).

The first scientific evidence of a link between a drug for severe acne anddepression was unveiled by Bath University in September 2006, followingyears of denials by Hoffmann׌a Roche that the prescription medicine couldbe in any way responsible for suicides.The research showed that the drug,which had been given to British teenagers for more than two decades, causesdepression in mice. Biochemist Dr Sarah Bailey looked at how healthy micewere affected by a six-week course of Roaccutane, which has a similarstructure to vitamin A. She found that when given levels of Roaccutaneequivalent to those used to treat teenagers, the creatures developedsymptoms of depression, stress or despair.

One study utilising positron emission tomography (PET) found that patientstreated with isotretinion experienced an average twenty-one percent decreasein frontal-lobe brain activity but showed no changes in depressive state inthe patients that could be measured with the Hamilton depression scale. Thisfinding has prompted members of the scientific community to call for morestudies regarding isotretinion’s links to depression and suicidal behavior.

Various case reports of depression, suicidal ideation, suicide attempt, andsuicide in patients treated with isotretinoin have been reported to the U.S.FDA Adverse Events Reporting System, with 431 cases reported between 1982and May 2001 ֠of these, 37 patients had committed suicide.  Thissuicide rate is in line with national rates and does not exceed the nationalaverage.

Studies have shown that patients with acne, the population group eligible toreceive isotretinoin therapy, have an increased risk of clinical depressioncompared with the general population.  Chee Hong describes Isotretinoin-relateddepression as “an idiosyncratic side-effect”, claiming, often anxiety canbring on acne and depression, creating more anxiety  Correspondingly,treatment of severe acne with isotretinoin has been shown to reduce anxietyand depression, for tests have shown acne to be a main depressant in mosttested patients’ lives.

U.S. Representative Bart Stupak (D-MI) believes unadvertised psychologicalside effects from the drug drove his teenage son, Bartholomew Thomas StupakJr., to commit suicide in 2000.

Crohn’s Disease and Ulcerative Colitis

Several scientific studies have posted that isotretinoin is a possible causeof Crohn’s Disease and Ulcerative colitis in some individuals. Three casesin the United States have gone to trial thus far, with all three resultingin multi-million dollar judgments against the makers of isotretinoin; thereare an additional 425 cases pending.

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